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Coumadin and Gabapentin interaction Treato Reducing the dose, discontinuing the drug, or substituting an alternative medication should be done gradually over a minimum of 1 week or longer Swallow Gralise tablets whole; do not cut, crush, or chew them Diplopia (6-10%) Nystagmus (6-10%) Tremor (6-10%) Amblyopia (1-5%) Back pain (1-5%) Constipation (1-5%) Depression (1-5%) Dry mouth (1-5%) Dysarthria (1-5%) Dyspepsia (1-5%) Hostility (5-8% children) Hyperkinesia (3-5%) Increased appetite (1-5%) Leukopenia (1-5%) Myalgia (1-5%) Nervousness (1-5%) Peripheral edema (1-5%) Pharyngitis (1-5%) Pruritus (1-5%) Rhinitis (1-5%) Vasodilation (1-5%) Weht gain (1-5%) Abnormal vision ( Angioedema Blood glucose fluctuation Breast enlargement Erythema multiforme Elevated liver function tests Fever Hyponatremia Jaundice Stevens-Johnson syndrome Adverse events following abrupt discontinuation have also been reported; the most frequently reported events have been anxiety, insomnia, nausea, pain, and sweating Increased blood CPK levels and rhabdomyolysis reported Antiepileptic drugs increase risk of suicidal thoughts or behavior in patients taking these drugs for any indication; monitor for emergence or worsening depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior Anaphylaxis and angioedema reported after first dose or at any time during treatment; instruct patients to discontinue therapy and seek medical care should they experience sns or symptoms of anaphylaxis or angioedema May cause CNS depression, which may impair ability to operate heavy machinery; advise patients not to drive until they have gained enough experience to assess whether therapy will impair ability to drive Extended release formulation (Garlise) not studied in the treatment of seizures Extended release formulation (Garlise), not interchangeable with immediate release May potentiate effects of other sedatives or ethanol when administered concomitantly Do not discontinue abruptly (may increase seizure frequency); gradually taper over a minimum of 1 week Ages 3-12 years: Risk of neuropsychiatric adverse events, including emotional lability, hostility, thought disorders, and hyperkinesia Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as multiorgan hypersensitivity, reported; some of these events have been fatal or life-threatening; typiy presents with fever, rash, and/or lymphadenopathy in association with other organ system involvement (eg, hepatitis, nephritis, hematologic abnormalities, myocarditis, myositis) and may resemble an acute viral infection GABA analogue; structurally related to neurotransmitter GABA, but has no effect on GABA binding, uptake, or degradation; presence of gabapentin binding sites throughout the brain reported; mechanism for analgesic and anticonvulsant activity unknown The above information is provided for general informational and educational purposes only. Can I take Coumadin with Gabapentin? There is no known interaction between Coumadin and Gabapentin in our records. However, an interaction may still exist.

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